Photoactivatable Caged Prodrugs of VEGFR-2 Kinase Inhibitors
نویسندگان
چکیده
منابع مشابه
Photoactivatable Caged Prodrugs of VEGFR-2 Kinase Inhibitors.
In this study, we report on the design, synthesis, photokinetic properties and in vitro evaluation of photoactivatable caged prodrugs for the receptor tyrosine kinase VEGFR-2. Highly potent VEGFR-2 inhibitors 1 and 3 were caged by introduction of a photoremovable protecting group (PPG) to yield the caged prodrugs 4 and 5. As expected, enzymatic and cellular proliferation assays showed dramatica...
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ژورنال
عنوان ژورنال: Molecules
سال: 2016
ISSN: 1420-3049
DOI: 10.3390/molecules21050570